researchers' research and development of a new portable blood analyzer can help improve global anemia detection.
anemia is a very common disease in developing countries, although it can be easily treated with iron supplements and vitamins, and a healthy diet is enough to prevent it
about a quarter of the world's population suffers from anaemia, a disease caused by insufficient hemoglobin concentration in red blood cells. In order to reduce the burden of anemia, health officials need to better understand the global impact of the disease, and this understanding becomes feasible by analyzing blood in a portable and affordable way
researchers at the University of Washington have developed a device smaller than a toaster that can use optical absorbance to detect hemoglobin levels in whole blood samples. This work was published on AIP advances of AIP publishing house this week
hemoglobin is a protein found in red blood cells, which can deliver oxygen to the whole body. With the decrease of hemoglobin concentration, the body is lack of oxygen, which often leads to dizziness, fatigue, shortness of breath and abnormal heart rate
currently, blood analyzers on the market measure hemoglobin by chemically destroying red blood cells in samples. This technology requires practical expertise to prepare and run samples, which limits the ability to monitor anemia in many parts of the world
"the most exciting aspect of this analyzer is that it uses whole blood and does not require additional steps and reagents to prepare samples," said Nathan snaadecki, an associate professor of mechanical engineering at the University of Washington and one of the authors
the device only needs a few drops of blood for analysis
"you just flow blood into the channel, that's it," said Nikita T, Ph.D. candidate of snaidecki laboratory and another author, room temperature tensile test method for metal materials gb/t228 ⑵ 002aparia. "It can be used anywhere."
the analyzer uses the optical properties of blood, such as absorption and scattering, to measure hemoglobin concentration. Anemia spreads more light than normal blood, so the severity of anemia can be measured as the ratio of transmitted light to original light intensity
in order to simulate anemia, researchers diluted blood samples with buffer solution. The hematology analyzer can effectively predict cases of moderate to severe anemia, which is defined as less than 10 grams of hemoglobin per deciliter of the sample. The analyzer did not produce any false negative results
the optical density of the sample does not increase linearly, so the higher concentration of hemoglobin defines the upper limit of the device
the main cause of anemia is iron deficiency, but it may occur together with other diseases, such as genetic diseases such as malaria and sickle cells. Severe anemia can lead to increased maternal and child mortality. It can also damage children's cognitive and physical development
materials such as towers can't be used directly under normal circumstances. Paria said, "it's really meaningful to complete a part of a project from the beginning and make a device that can really help people." "The analyzer is suitable for people with diseases."
the current design is a prototype that can be integrated with other microfluidic devices, and its utilization range is unparalleled, so as to analyze whole blood samples in parallel to diagnose anemia and other potential factors that may lead to disease